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3 Jan general biotransformation reactions occurring in organisms Biotransformation Presented By PreetHi. . thank you for this good ppt. 2 years. 11 Jan Drugs which do not undergo biotransformation – Streptomycin, neostigmine.( highly Drug Biotransformation – convert lipophilic / hydrophobic drug (to enter cells) to hydrophilic metabolites. . Protein binding of 11 Apr thank you for this good ppt. 2 years ago Reply Major site of drugs biotransformation isMajor site of drugs biotransformation is LIVERLIVER.. 8.
They tend to store in fat and/or circulate until they are converted (phase I biotransformation) to more water soluble metabolites or metabolites that conjugate. Metabolism - Biotransformation. Supplementary readings: Casarett and Doull, Chapter 6. Timbrell, Chapters 4 and 5. Non-polar. (lipophilic). Hydrophobic. 11 Jan BIOTRANSFORMATION Ppt - authorSTREAM Presentation.
Biotransformation Xenobiotic metabolism. “Essentials of Toxicology”. by Klaassen Curtis D. and Watkins John B Chapter 6. Biotransformation. Water soluble. PART A: Biotransformation reactions. • Introduction. • Phase I reactions. • Phase II reacions. • The effect of biotransformation on the biological activity of drugs. Biotransformation. The elimination of xenobiotics often depends on their conversion to water-soluble chemicals through biotransformation, catalyzed by multiple. 1 Why is drug biotransformation necessary. □ 2 The role of biotransformation in drug disposition. □ 3 Where do drug biotransformation occur. □ 4 The enzymes . Resorption into blood stream; Distribution into tissues; Biotransformation into metabolites; Elimination ways: a) Urine – polar compounds. b) Feaces – lipophilic.
BIOTRANSFORMATION Prof. Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D Department of Pharmaceutics KLE University s College of Pharmacy BELGAUM . Schematic chart of metabolizing organ – A free PowerPoint PPT presentation ( displayed as a Flash slide show) on - id: ea0-ZWNhM. Phase 1: Biotransformation. Attachment of new functional groups, transformation of exist. funct. groups. oxidation, reduction, hydroxylation, hydrolysis etc. Biotransformation is the metabolic conversion of endogenous and xenobiotic chemicals to more .. View Full Size|Favorite Figure|Download Slide .ppt).
24 Dec Department of Biotransformation, Drug Metabolism and Pharmacokinetics Unit, Sai Life Sciences Limited, International Biotech Park, Phase-II. Non-toxic metabolite. Toxic metabolite. EXCRET. IO. N. Definition. Biotransformation is the sum of all processes, whereby a compound is transformed chemically. The structures and possible biotransformation pathways of PPD- and PPT-type ginsenosides by microbial or enzymatic methods are shown in Fig. 1. knowledge, biotransformation of Rf into PPT(S) has not been reported. Conversion and transformation pathways are discussed below. This biotransformation.